The Cleveland Guardians are set to battle it out against the St. Louis Cardinals at Busch Stadium on September 21, 2024, beginning promptly at 07:15 pm. The conditions forecast an overcast environment enhancing the game day atmosphere.

Matthew Boyd of the Cleveland Guardians, who presents an impressive ERA of 2.523, is slated to start as pitcher. His counterpart from the St. Louis Cardinals will be Miles Mikolas, with a current ERA of 5.490. The Guardians, well-positioned at second in the 2024 AL Central Division with a record of 90 wins and 65 losses, showcase a commendable .580 winning percentage. They have also recorded 30 divisional victories. In contrast, the Cardinals have balanced their season with a 77-77 record, standing ninth in the NL Central Division and holding a .500 winning percentage.

Exploring the betting landscape, the odds lean slightly in favor of the Guardians. With a point spread of 1.5, the clash expects a relatively close contest. The over/under is set at 8.0, hinting at moderate scoring anticipated by bookmakers. Bettors might prefer taking advantage of the -135 Away Team Money Line for the Guardians, whereas the underdog Cardinals stand at +116 at home, possibly enticing for those favoring a tighter contest. This disparity in money lines underscores the contrasting seasonal performances and the possible impact of the starting pitchers.